Department of Zoology, West Bengal State University, Berunanpukuria, Malikapur, North-24 Parganas, Barasat, Kolkata 7000126, West Bengal, India.
Chem Biol Interact. 2012 Feb 5;195(3):231-9. doi: 10.1016/j.cbi.2012.01.001. Epub 2012 Jan 21.
Cinnamic acid (C9H8O2), is a major constituent of the oriental Ayurvedic plant Cinnamomum cassia (Family: Lauraceae). This phenolic acid has been reported to possess various pharmacological properties of which its antioxidant activity is a prime one. Therefore it is rational to hypothesize that it may ameliorate myelosuppression and oxidative stress induced by cyclophosphamide, a widely used chemotherapeutic agent. Commercial cyclophosphamide, Endoxan, was administered intraperitoneally to Swiss albino mice (50mg/kg) pretreated with 15, 30 and 60mg/kg doses of cinnamic acid orally at alternate days for 15days. Cinnamic acid pre-treatment was found to reduce cyclophosphamide induced hypocellularity in the bone marrow and spleen. This recovery was also reflected in the peripheral blood count. Amelioration of hypocellularity could be correlated with the modulation of cell cycle phase distribution. Cinnamic acid pre-treatment reduced bone marrow and hepatic oxidative stress as evident by lipid peroxidation and activity assays of antioxidant enzymes such as superoxide dismutase, catalase and glutathione-S-transferase. The present study indicates that cinnamic acid pretreatment has protective influence on the myelosuppression and oxidative stress induced by cyclophosphamide. This investigation is an attempt and is the first of its kind to establish cinnamic acid as an agent whose consumption provides protection to normal cells from the toxic effects of a widely used anti-cancer drug.
桂皮酸（C9H8O2）是东方阿育吠陀植物肉桂（樟科）的主要成分。这种酚酸已被报道具有多种药理作用，其中抗氧化活性是主要作用之一。因此，可以合理假设它可以改善环磷酰胺引起的骨髓抑制和氧化应激，环磷酰胺是一种广泛使用的化疗药物。将市售环磷酰胺（Endoxan）以 50mg/kg 的剂量腹腔内给药，并用 15、30 和 60mg/kg 剂量的桂皮酸经口每天交替给药 15 天预处理瑞士白化小鼠。桂皮酸预处理可减少环磷酰胺诱导的骨髓和脾脏细胞减少症。这种恢复也反映在外周血象中。细胞减少症的改善可能与细胞周期相分布的调节有关。桂皮酸预处理可减少骨髓和肝脏的氧化应激，如脂质过氧化和抗氧化酶（如超氧化物歧化酶、过氧化氢酶和谷胱甘肽-S-转移酶）的活性测定。本研究表明，桂皮酸预处理对环磷酰胺引起的骨髓抑制和氧化应激具有保护作用。这项研究是一种尝试，也是首次将桂皮酸作为一种可以使正常细胞免受广泛使用的抗癌药物的毒性作用的保护剂。
