Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
J Control Release. 2012 Jul 20;161(2):446-60. doi: 10.1016/j.jconrel.2011.12.021. Epub 2011 Dec 29.
Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.
聚合物缀合是一种有效的方法，可以改善药物和生物制剂的传递，既能通过改善生物分布和降低毒性来保护身体免受药物侵害，又能通过防止降解和增强细胞摄取来保护药物免受身体侵害。本文综述了聚合物治疗剂在体内遵循 ADME（吸收、分布、代谢、排泄）概念的旅程。将描述影响该过程每个阶段的生物因素和输送系统参数，并举例说明体内药物输送系统面临的不同挑战的解决方案。
