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纳米医学的闪亮铠甲：理解并利用金属-酚醛网络

Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks.

作者信息

Tang Zhengming, Huang Zhijie, Huang Yisheng, Huang Mingshu, Liu Hongyu, Du JianZhong, Jia Bo

机构信息

Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

Yuexiu District Stomatological Hospital, Guangzhou, Guangdong, China.

出版信息

J Nanobiotechnology. 2025 Mar 2;23(1):158. doi: 10.1186/s12951-025-03210-7.

DOI:10.1186/s12951-025-03210-7
PMID:40025537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11874145/
Abstract

Metal-phenolic networks (MPNs), which comprise supramolecular amorphous networks formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis of the cumulative research advancements and utilizations of MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate the characteristic polyphenols, metal ions, and their intricate interaction modalities within MPNs. Subsequently, it elucidates the merits and demerits of diverse synthesis methodologies employed for MPNs, alongside exploring their potential functional attributes. Furthermore, it consolidates the diverse applications of MPNs across various nanomedical domains encompassing tumor therapy, antimicrobial interventions, medical imaging, among others. Moreover, a meticulous exposition of the journey of MPNs from their ingress into the human body to eventual excretion is provided. Lastly, the persistent challenges and promising avenues pertaining to MPNs are delineated. Hence, this review offering a comprehensive exposition on the current advancements of MPNs in nanomedicine, consequently offering indirect insights into their potential clinical implementation.

摘要

金属-酚醛网络（MPNs）是由多酚与金属离子交联形成的超分子无定形网络，在纳米医学领域越来越受到关注。目前，关于MPNs在纳米医学中的累积研究进展和应用尚无全面综述。因此，本综述首先试图描述MPNs中特征性的多酚、金属离子及其复杂的相互作用方式。随后，阐述了用于MPNs的各种合成方法的优缺点，并探索了它们潜在的功能特性。此外，还总结了MPNs在肿瘤治疗、抗菌干预、医学成像等各种纳米医学领域的不同应用。此外，还详细阐述了MPNs从进入人体到最终排泄的过程。最后，描述了与MPNs相关的持续挑战和有前景的途径。因此，本综述全面阐述了MPNs在纳米医学中的当前进展，从而间接洞察其潜在的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/9b6f5e5a9aa0/12951_2025_3210_Fig13_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/9b6f5e5a9aa0/12951_2025_3210_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/c1ab44c88c54/12951_2025_3210_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/eb71ed2cfdd9/12951_2025_3210_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/013c9fc01579/12951_2025_3210_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/81234825b426/12951_2025_3210_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/50a8251ba1dd/12951_2025_3210_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/99f6784055a3/12951_2025_3210_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/5f6c383fb30e/12951_2025_3210_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/1018a13b73d2/12951_2025_3210_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/fc56b643b9ee/12951_2025_3210_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/95ac83f8c625/12951_2025_3210_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/5a840489a586/12951_2025_3210_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d3e/11874145/9b6f5e5a9aa0/12951_2025_3210_Fig13_HTML.jpg

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