血管抑制素-1可抑制结肠癌。
Vasohibin-1 suppresses colon cancer.
作者信息
Liu Shuai, Han Bing, Zhang Qunyuan, Dou Jie, Wang Fang, Lin Wenli, Sun Yuping, Peng Guangyong
机构信息
Department of Oncology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, P. R. China.
Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
出版信息
Oncotarget. 2015 Apr 10;6(10):7880-98. doi: 10.18632/oncotarget.3493.
Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor.However, the clinical relevance of VASH1 in colon cancer and its regulations on cancer angiogenesis and cancer cell biological characteristics are still unknown. Here we showed that stromal VASH1 levels were negatively correlated with tumor size, advanced clinical stage and distant metastases in colon cancer patients. Overexpression of VASH1 in colon cancer cells induced apoptosis and senescence, inhibiting cancer cell growth and colony formation in vitro and tumor growth in vivo. In addition, knockdown of VASH1 in cancer cells promoted cell growth, adhesion and migration in vitro, and enhanced tumorigenesis and metastasis in vivo.
血管抑制素-1（VASH1）是一种内源性血管生成抑制剂。然而，VASH1在结肠癌中的临床相关性及其对肿瘤血管生成和癌细胞生物学特性的调控仍不清楚。在此我们表明，结肠癌患者基质中VASH1水平与肿瘤大小、临床晚期及远处转移呈负相关。在结肠癌细胞中过表达VASH1可诱导细胞凋亡和衰老，在体外抑制癌细胞生长和集落形成，在体内抑制肿瘤生长。此外，敲低癌细胞中的VASH1可促进体外细胞生长、黏附和迁移，并增强体内肿瘤发生和转移。
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