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本文引用的文献

1
Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae.环二鸟苷酸和群体感应在霍乱弧菌 vpsT 和 aphA 调控中的整合。
J Bacteriol. 2011 Nov;193(22):6331-41. doi: 10.1128/JB.05167-11. Epub 2011 Sep 16.
2
H-NS binding and repression of the ctx promoter in Vibrio cholerae.H-NS 结合并抑制霍乱弧菌 ctx 启动子的活性。
J Bacteriol. 2011 Feb;193(4):979-88. doi: 10.1128/JB.01343-09. Epub 2010 Dec 17.
3
Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae.生物膜中的生长会诱导霍乱弧菌产生超感染表型。
Infect Immun. 2010 Aug;78(8):3560-9. doi: 10.1128/IAI.00048-10. Epub 2010 Jun 1.
4
Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis.Vibrio 多糖(vps)基因在 VPS 产生、生物膜形成和霍乱弧菌发病机制中的作用。
Microbiology (Reading). 2010 Sep;156(Pt 9):2757-2769. doi: 10.1099/mic.0.040196-0. Epub 2010 May 13.
5
Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.霍乱弧菌 VpsT 通过直接感应环二鸟苷酸来调节基质产生和运动性。
Science. 2010 Feb 12;327(5967):866-8. doi: 10.1126/science.1181185.
6
The virulence transcriptional activator AphA enhances biofilm formation by Vibrio cholerae by activating expression of the biofilm regulator VpsT.毒力转录激活因子 AphA 通过激活生物膜调控因子 VpsT 的表达增强霍乱弧菌的生物膜形成。
Infect Immun. 2010 Feb;78(2):697-703. doi: 10.1128/IAI.00429-09. Epub 2009 Nov 23.
7
The PhoB regulatory system modulates biofilm formation and stress response in El Tor biotype Vibrio cholerae.PhoB 调控系统调节 El Tor 生物型霍乱弧菌生物膜形成和应激反应。
FEMS Microbiol Lett. 2010 Jan;302(1):22-31. doi: 10.1111/j.1574-6968.2009.01837.x. Epub 2009 Oct 28.
8
PhoB regulates motility, biofilms, and cyclic di-GMP in Vibrio cholerae.PhoB调节霍乱弧菌的运动性、生物膜和环二鸟苷酸。
J Bacteriol. 2009 Nov;191(21):6632-42. doi: 10.1128/JB.00708-09. Epub 2009 Sep 4.
9
DNA bridging and antibridging: a role for bacterial nucleoid-associated proteins in regulating the expression of laterally acquired genes.DNA桥接与抗桥接:细菌类核相关蛋白在调控横向获得基因表达中的作用
FEMS Microbiol Rev. 2009 May;33(3):587-92. doi: 10.1111/j.1574-6976.2008.00155.x. Epub 2008 Dec 22.
10
Role of the histone-like nucleoid structuring protein in the regulation of rpoS and RpoS-dependent genes in Vibrio cholerae.组蛋白样类核结构蛋白在霍乱弧菌中对rpoS及RpoS依赖性基因的调控作用
J Bacteriol. 2008 Nov;190(22):7335-45. doi: 10.1128/JB.00360-08. Epub 2008 Sep 12.

组蛋白样核区结构蛋白(H-NS)是霍乱弧菌荚膜多糖生物合成(vps)基因的抑制剂。

The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes.

机构信息

Southern Research Institute, Drug Discovery Division, Department of Biochemistry and Molecular Biology, Birmingham, Alabama, USA.

出版信息

Appl Environ Microbiol. 2012 Apr;78(7):2482-8. doi: 10.1128/AEM.07629-11. Epub 2012 Jan 27.

DOI:10.1128/AEM.07629-11
PMID:22287003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3302599/
Abstract

The capacity of Vibrio cholerae to form biofilms has been shown to enhance its survival in the aquatic environment and play important roles in pathogenesis and disease transmission. In this study, we demonstrated that the histone-like nucleoid structuring protein is a repressor of exopolysaccharide (vps) biosynthesis genes and biofilm formation.

摘要

霍乱弧菌形成生物膜的能力已被证明可以增强其在水生环境中的生存能力,并在发病机制和疾病传播中发挥重要作用。在这项研究中,我们证明了组蛋白样核结构蛋白是外多糖(vps)生物合成基因和生物膜形成的抑制剂。