Southern Research Institute, Drug Discovery Division, Department of Biochemistry and Molecular Biology, Birmingham, Alabama, USA.
Appl Environ Microbiol. 2012 Apr;78(7):2482-8. doi: 10.1128/AEM.07629-11. Epub 2012 Jan 27.
The capacity of Vibrio cholerae to form biofilms has been shown to enhance its survival in the aquatic environment and play important roles in pathogenesis and disease transmission. In this study, we demonstrated that the histone-like nucleoid structuring protein is a repressor of exopolysaccharide (vps) biosynthesis genes and biofilm formation.
霍乱弧菌形成生物膜的能力已被证明可以增强其在水生环境中的生存能力,并在发病机制和疾病传播中发挥重要作用。在这项研究中,我们证明了组蛋白样核结构蛋白是外多糖(vps)生物合成基因和生物膜形成的抑制剂。