Brehm Walter, Burk Janina, Delling Uta, Gittel Claudia, Ribitsch Iris
Large Animal Clinic for Surgery, University of Leipzig, An den Tierkliniken 21, 04103, Leipzig, Germany,
Cell Tissue Res. 2012 Mar;347(3):677-688. doi: 10.1007/s00441-011-1316-1. Epub 2012 Jan 28.
Regenerative medicine is one of the most intensively researched medical branches, with enormous progress every year. When it comes to translating research from bench to bedside, many of the pioneering innovations are achieved by cooperating teams of human and veterinary medical scientists. The veterinary profession has an important role to play in this new and evolving technology, holding a great scientific potential, because animals serve widely as models for human medicine and results obtained from animals may serve as preclinical results for human medicine. Regenerative veterinary medicine utilizing mesenchymal stromal cells (MSC) for the treatment of acute injuries as well as chronic disorders is gradually turning into clinical routine. As orthopaedic disorders represent a major part of all cases in veterinary clinical practice, it is not surprising that they are currently taking a leading role in MSC therapies. Therefore, the purpose of this paper is to give an overview on past and current achievements as well as future perspectives in stem cell-based tissue engineering in veterinary orthopaedics.
再生医学是研究最为深入的医学分支之一，每年都有巨大进展。在将研究成果从实验室转化到临床应用方面，许多开创性创新是由人类医学和兽医学科学家组成的合作团队实现的。兽医行业在这项新兴且不断发展的技术中发挥着重要作用，具有巨大的科学潜力，因为动物广泛用作人类医学的模型，从动物身上获得的结果可作为人类医学的临床前结果。利用间充质基质细胞（MSC）治疗急性损伤和慢性疾病的再生兽医学正逐渐成为临床常规操作。由于骨科疾病在兽医临床实践中占所有病例的很大一部分，它们目前在MSC治疗中占据主导地位也就不足为奇了。因此，本文旨在概述兽医骨科基于干细胞的组织工程的过去和当前成就以及未来前景。
