hedgehog 信号分子的表达作为口腔鳞状细胞癌的预后指标。
Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma.
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
出版信息
Head Neck. 2012 Nov;34(11):1556-61. doi: 10.1002/hed.21958. Epub 2012 Jan 27.
BACKGROUND
Recent studies have indicated hedgehog pathway plays a role in carcinogenesis of certain cancers. We investigated the clinical significance of its signaling components, including Sonic hedgehog (Shh), Patched (Ptch), and Gli-1, in oral squamous cell carcinoma (OSCC).
METHODS
By immunohistochemistry, we determined Shh, Ptch, and Gli-1 expression in surgical specimens from 40 patients with OSCC. The relationship between expression of these molecules and clinicopathologic variables were assessed by chi-square analysis. Statistical difference of survival was compared using log-rank test.
RESULTS
Ptch overexpression was associated with lymphatic metastasis (p = .028). Nuclear Gli-1 overexpression correlated with primary tumor size (p = .001), lymphatic metastasis (p = .011), and tumor recurrence (p = .008). Overexpression of Ptch (p = .020) or Gli-1 (p = .002) in OSCC indicated poor prognosis in the univariate survival analysis.
CONCLUSION
Our results suggest sonic hedgehog (Shh) pathway plays an important role in OSCC progression and should be considered a potential therapeutic target.
背景
最近的研究表明 hedgehog 通路在某些癌症的致癌作用中起作用。我们研究了其信号成分，包括 Sonic hedgehog（Shh）、Patched（Ptch）和 Gli-1，在口腔鳞状细胞癌（OSCC）中的临床意义。
方法
通过免疫组织化学，我们确定了 40 例 OSCC 手术标本中 Shh、Ptch 和 Gli-1 的表达。通过卡方分析评估这些分子的表达与临床病理变量之间的关系。使用对数秩检验比较生存的统计学差异。
结果
Ptch 过表达与淋巴转移有关（p =.028）。核 Gli-1 过表达与原发肿瘤大小（p =.001）、淋巴转移（p =.011）和肿瘤复发（p =.008）相关。OSCC 中 Ptch（p =.020）或 Gli-1（p =.002）的过表达在单变量生存分析中预示预后不良。
结论
我们的结果表明 sonic hedgehog（Shh）通路在 OSCC 进展中起重要作用，应被视为潜在的治疗靶点。
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