The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Department of Otolaryngology, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
Head Neck. 2013 Feb;35(2):294-306. doi: 10.1002/hed.21975. Epub 2012 Jan 27.
Head and neck oncologists have traditionally relied on clinical tumor features and patient characteristics to guide care of individual patients. As surgical, radiotherapeutic, and systemic treatments have evolved to become more anatomically precise and mechanistically specific, the opportunity for improved cure and functional patient recovery has never been more promising for this historically debilitating cancer. However, personalized treatment must be accompanied by sophisticated patient selection to triage the application of advanced therapies toward ideal patient candidates. In this monograph, we review current progress, investigative themes, and key challenges facing head and neck cancer biomarker development intended to make personalized head and neck cancer treatment a clinical reality.
头颈部肿瘤学家传统上依赖于临床肿瘤特征和患者特征来指导对个体患者的治疗。随着手术、放射治疗和系统治疗变得更加精确和具有特定机制，这种历来使人衰弱的癌症的治愈和功能恢复的机会从未像现在这样充满希望。然而，个性化治疗必须辅以精细的患者选择，以便将先进治疗方法应用于理想的患者候选者。在本专论中，我们回顾了旨在使个性化头颈部癌症治疗成为临床现实的头颈部癌症生物标志物开发的当前进展、研究主题和关键挑战。
