中性粒细胞与淋巴细胞比值作为头颈部癌症预后指标的系统评价和荟萃分析。
Neutrophil-to-lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta-analysis.
机构信息
New York Head and Neck Institute, Hofstra Northwell School of Medicine, Northwell Health System, New York, New York.
Hofstra Northwell School of Medicine, New York, New York.
出版信息
Head Neck. 2018 Nov;40(11):2546-2557. doi: 10.1002/hed.25324. Epub 2018 May 14.
BACKGROUND
The purposes of this systematic review and meta-analysis were to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis in head and neck cancer.
METHODS
A systematic review and meta-analysis were done to investigate the role of NLR in overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and progression-free survival (PFS).
RESULTS
For qualitative analysis, 33 cohorts with over 10 072 patients were included. For quantitative analysis, 15 studies were included with 5562 patients. The pooled data demonstrated that an elevated NLR significantly predicted poorer OS and DSS.
CONCLUSION
An elevated pretreatment NLR is a prognostic marker for head and neck cancer. It represents a simple and easily obtained marker that could be used to stratify groups of high-risk patients who might benefit from adjuvant therapy.
背景
本系统评价和荟萃分析的目的是研究中性粒细胞与淋巴细胞比值（NLR）与头颈部癌症预后之间的关系。
方法
进行了系统评价和荟萃分析，以研究 NLR 在总生存率（OS）、疾病特异性生存率（DSS）、无病生存率（DFS）和无进展生存率（PFS）中的作用。
结果
定性分析纳入了 33 项队列研究，超过 10072 例患者；定量分析纳入了 15 项研究，共 5562 例患者。汇总数据表明，升高的 NLR 显著预示着较差的 OS 和 DSS。
结论
术前升高的 NLR 是头颈部癌症的预后标志物。它代表了一种简单且易于获得的标志物，可以用于分层高危患者，这些患者可能受益于辅助治疗。
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