Department of Medicine, Faculty of Medicine, 123 Mitraparp Road, Khon Kaen 40002, Thailand.
Sex Transm Infect. 2012 Apr;88(3):177-8. doi: 10.1136/sextrans-2011-050201. Epub 2012 Jan 27.
The recommended treatment of otosyphilis is intravenous penicillin therapy. The response rate varied between 23% and 31%. This treatment needs hospitalisation and is costly, inconvenient and time consuming. Oral doxycycline was tested for its efficacy in otosyphilis.
The authors reviewed 19 patients diagnosed as having otosyphilis with hearing loss at the outpatient unit between 2004 and 2008 by oral doxycycline 400 mg/day for 21 days.
Of those enrolled patients, 12 patients were male and the mean age is 69.4 years. The hearing was improved in nine patients (47.3%) and the audiogram of seven patients (36.8%) showed improvement. There was no serious side effect of doxycycline.
The data suggest that doxycycline may be an effective alternate regimen for otosyphilis.
推荐使用青霉素静脉滴注治疗耳梅毒。其应答率在 23%至 31%之间变化。这种治疗需要住院，且费用高、不便且耗时。本文研究了口服强力霉素治疗耳梅毒的疗效。
作者回顾性分析了 2004 年至 2008 年间在门诊被诊断为耳梅毒伴听力损失的 19 例患者，给予口服强力霉素 400mg/天，疗程 21 天。
纳入的 19 例患者中，男性 12 例，平均年龄 69.4 岁。9 例（47.3%）患者听力改善，7 例（36.8%）患者的听力图显示改善。未出现强力霉素的严重副作用。
数据表明，强力霉素可能是治疗耳梅毒的有效替代方案。
