Chotmongkol Verajit, Khamsai Sittichai, Vatanasapt Patravoot, Sawanyawisuth Kittisak
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
North-Eastern Stroke Research Group, Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Research and Training Center for Enhancing Quality of Life of Working Age People, and Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen 40002, Thailand.
Antibiotics (Basel). 2019 Apr 28;8(2):47. doi: 10.3390/antibiotics8020047.
Otosyphilis is one contributing cause of hearing loss in adult patients. There are limited studies on the treatment regimens of otosyphilis. Penicillin G sodium (PGS) plus additional medications, such as benzathine penicillin and probenecid, is an effective regimen. This study investigated the efficacy of PGS alone for the treatment of otosyphilis. We conducted a retrospective study and included all consecutive patients diagnosed with otosyphilis who received only PGS treatment. The study period was from 2009 to 2013. The PGS treatment regimen was PGS 4 mu intravenously every four hours (24 mu/day) for 14 days. Clinical and audiogram outcomes were evaluated one year after treatment. There were 34 otosyphilis patients that were treated with PGS. After one year of treatment, 18 patients (52.9%) had a clinical improvement and 11 patients (32.4%) had an audiogram improvement. In conclusion, PGS at 24 mu/day for two weeks provided an audiogram improvement one year after treatment in one-third of the patients.
耳梅毒是成年患者听力损失的一个促成因素。关于耳梅毒治疗方案的研究有限。青霉素G钠（PGS）加用其他药物，如苄星青霉素和丙磺舒，是一种有效的治疗方案。本研究调查了单用PGS治疗耳梅毒的疗效。我们进行了一项回顾性研究，纳入了所有连续诊断为耳梅毒且仅接受PGS治疗的患者。研究时间段为2009年至2013年。PGS治疗方案为每四小时静脉注射400万单位PGS（每日2400万单位），持续14天。治疗一年后评估临床和听力图结果。有34例耳梅毒患者接受了PGS治疗。治疗一年后，18例患者（52.9%）临床症状改善，11例患者（32.4%）听力图改善。总之，每日2400万单位的PGS治疗两周后，三分之一的患者在治疗一年后听力图得到改善。
