Anuchin A M, Goncharenko A V, Demidenok O I, Kaprel'iants A S
Prikl Biokhim Mikrobiol. 2011 Nov-Dec;47(6):635-41.
Four major families of bacterial histone-like proteins (HU, IHF, H-NS, FIS), united on the basis of structural similarity and performing specific structural and regulatory functions in the cell, are discussed. Histone-like proteins perform topological modification of the chromosome (twisting, bending, and folding) and directly regulate the functioning of promoters of individual operons. Histone-like proteins are critical for the regulation of cell metabolism, are involved in the response to environmental changes, and play a key role in the transition to and maintenance of the quiescent state of bacteria.
本文讨论了四大类细菌组蛋白样蛋白（HU、IHF、H-NS、FIS），它们基于结构相似性归为一类，并在细胞中执行特定的结构和调节功能。组蛋白样蛋白对染色体进行拓扑修饰（扭曲、弯曲和折叠），并直接调节各个操纵子启动子的功能。组蛋白样蛋白对细胞代谢的调节至关重要，参与对环境变化的反应，并在细菌静止状态的转变和维持中起关键作用。
