膜稳态与功能的化学生物学研究方法。
Chemical biology approaches to membrane homeostasis and function.
作者信息
Takahashi-Umebayashi Miwa, Pineau Ludovic, Hannich Thomas, Zumbuehl Andreas, Doval David Alonso, Matile Stefan, Heinis Christian, Turcatti Gerardo, Loewith Robbie, Roux Aurélien, Reymond Luc, Johnsson Kai, Riezman Howard
机构信息
Departments of Biochemistry, Organic Chemistry and Molecular Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
出版信息
Chimia (Aarau). 2011;65(11):849-52. doi: 10.2533/chimia.2011.849.
The study of membranes is at a turning point. New theories about membrane structure and function have recently been proposed, however, new technologies, combining chemical, physical, and biochemical approaches are necessary to test these hypotheses. In particular, the NCCR in chemical biology aims to visualize and characterize membrane microdomains and determine their function during hormone signaling.
膜的研究正处于一个转折点。最近提出了关于膜结构和功能的新理论，然而，需要结合化学、物理和生物化学方法的新技术来检验这些假设。特别是，化学生物学领域的国家研究能力中心旨在对膜微区进行可视化和表征，并确定它们在激素信号传导过程中的功能。
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