Puth Kristina, Hofbauer Harald F, Sáenz James P, Ernst Robert
Biol Chem. 2015 Sep;396(9-10):1043-58. doi: 10.1515/hsz-2015-0130.
Biological membranes are dynamic and complex assemblies of lipids and proteins. Eukaryotic lipidomes encompass hundreds of distinct lipid species and we have only begun to understand their role and function. This review focuses on recent advances in the field of lipid sensors and discusses methodical approaches to identify and characterize putative sensor domains. We elaborate on the role of integral and conditionally membrane-associated sensor proteins, their molecular mechanisms, and identify open questions in the emerging field of membrane homeostasis.
生物膜是脂质和蛋白质动态且复杂的集合体。真核生物脂质组包含数百种不同的脂质种类，而我们才刚刚开始了解它们的作用和功能。本综述聚焦于脂质传感器领域的最新进展，并讨论用于识别和表征假定传感器结构域的方法学途径。我们详细阐述了整合型和条件性膜相关传感器蛋白的作用、它们的分子机制，并确定了膜稳态这一新兴领域中尚未解决的问题。
