Leis Karen S, McNally J Dayre, Montgomery Matthew R, Sankaran Koravangattu, Karunanayake Chandima, Rosenberg Alan M
Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jan;14(1):1-6.
To determine if vitamin D intake is associated with acute lower respiratory infections (ALRI) in children.
The vitamin D intakes of children younger than 5 years of age admitted to hospital with either bronchiolitis or pneumonia were compared to an unmatched control group of the same age without respiratory infection. Caregivers of 197 children completed a questionnaire collecting information on demographic variables, ALRI risk factors and diet. Associations of ALRI with vitamin D intake and other ALRI risk factors were determined.
The mean vitamin D intake of children with ALRI was 48 IU/kg/d compared to 60 IU/kg/d in the control group. When controlling for age, ethnicity, socio-economic status, northern residence, breastfeeding, immunizations and smoking contact, children with a vitamin D intake of less than 80 IU/kg/d were greater than 4 times more likely to have ALRI compared to children with a vitamin D intake exceeding 80 IU/kg/d (OR=4.9; 95%CI: 1.5-16.4).
A higher vitamin D intake than currently recommended might be needed to offer protection against diseases such as ALRI. Increased vitamin D supplementation could have important public health consequences, as bronchiolitis and pneumonia are the most common reasons for hospitalization in young children. (Full English version will be available online at www.amepc.org/tp.).
确定维生素D摄入量与儿童急性下呼吸道感染(ALRI)是否相关。
将因细支气管炎或肺炎入院的5岁以下儿童的维生素D摄入量与年龄匹配但无呼吸道感染的对照组进行比较。197名儿童的照料者完成了一份问卷,收集有关人口统计学变量、ALRI危险因素和饮食的信息。确定ALRI与维生素D摄入量及其他ALRI危险因素之间的关联。
患ALRI儿童的维生素D平均摄入量为48 IU/kg/天,而对照组为60 IU/kg/天。在控制年龄、种族、社会经济地位、居住在北方、母乳喂养、免疫接种和吸烟接触等因素后,维生素D摄入量低于80 IU/kg/天的儿童患ALRI的可能性是维生素D摄入量超过80 IU/kg/天儿童的4倍多(比值比=4.9;95%置信区间:1.5-16.4)。
可能需要比目前推荐量更高的维生素D摄入量来预防诸如ALRI等疾病。增加维生素D补充可能会产生重要的公共卫生影响,因为细支气管炎和肺炎是幼儿住院的最常见原因。(完整英文版本可在www.amepc.org/tp.在线获取。)