Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, South Korea.
J Neurol. 2012 Aug;259(8):1706-12. doi: 10.1007/s00415-011-6404-3.
Ample evidence has suggested that individuals with subjective memory complaints are at a higher risk for cognitive decline. Nevertheless, the significance of subjective memory complaints in Parkinson’s disease has not been studied until now. We investigated whether the patterns of cognitive profiles and gray matter density differed in cognitively normal patients with Parkinson’s disease based on the presence of subjective memory complaints. Using a single question with a yes or no answer, cognitively normal patients with Parkinson’s disease were classified as with (n = 20) or without subjective memory complaints (n = 15). Cognitive profiles and gray matter density were examined using standardized neuropsychological tests and voxel-based morphometry. No significant differences in demographic characteristics were observed between groups. The detailed neuropsychological tests demonstrated that Parkinson’s disease patients with subjective memory complaints had significantly decreased verbal fluency and slightly lower scores on the backward digit-span test compared with those without subjective memory complaints. A voxel-based morphometry analysis revealed that Parkinson’s disease patients with subjective memory complaints had significantly decreased gray matter density in the anterior cingulate gyrus and right inferior parietal lobule compared with those without subjective memory complaints. Our data demonstrated that Parkinson’s disease patients with subjective memory complaints showed a poorer performance on tasks related to verbal fluency and attention with more severe cortical atrophy compared to those without subjective memory complaints, suggesting that subjective memory complaints in patients with Parkinson’s disease may represent an early manifestation of underlying Parkinson’s disease-related pathological changes.
大量证据表明，有主观记忆主诉的个体发生认知衰退的风险更高。然而，直到现在，主观记忆主诉在帕金森病中的意义仍未得到研究。我们研究了基于是否存在主观记忆主诉，帕金森病认知正常患者的认知特征和灰质密度模式是否存在差异。我们使用一个有或没有的简单问题来对帕金森病认知正常患者进行分类，即存在主观记忆主诉的患者（n = 20）或不存在主观记忆主诉的患者（n = 15）。我们使用标准化神经心理学测试和基于体素的形态计量学来检查认知特征和灰质密度。两组间的人口统计学特征无显著差异。详细的神经心理学测试表明，与无主观记忆主诉的患者相比，有主观记忆主诉的帕金森病患者的言语流畅性明显下降，倒背数字广度测试的得分略低。基于体素的形态计量学分析显示，与无主观记忆主诉的患者相比，有主观记忆主诉的帕金森病患者的前扣带回和右侧顶下小叶的灰质密度明显降低。我们的数据表明，与无主观记忆主诉的患者相比，有主观记忆主诉的帕金森病患者在与言语流畅性和注意力相关的任务上表现更差，且皮质萎缩更严重，这表明帕金森病患者的主观记忆主诉可能代表潜在的帕金森病相关病理变化的早期表现。
