Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Molecules. 2012 Jan 30;17(2):1191-202. doi: 10.3390/molecules17021191.
The present study investigates the effect of pre-treatment with Salvia miltiorrhiza ethanol extracts (SMEE) on renal function markers, immunity and antioxidant activities in renal ischemia and reperfusion (IR) rats. Wistar rat kidneys were subjected to 60 min of global ischemia at 37 °C followed by 30 min of reperfusion, and were randomly assigned into the sham, IR model and three SMEE-treated groups (n = 8 per group). Results showed that high serum creatinin (Scr), blood urea nitrogen (BUN), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) and malondialhehyde (MDA) levels, and low antioxidant enzyme activities were observed in IR rats compared to the sham rats. Pre-treatment of Salvia miltiorrhiza ethanol extracts for 20 days prior to IR operation improved renal function, reduced IR induced renal inflammatory and oxidative injury. It is concluded that Salvia miltiorrhiza ethanol extracts could be beneficial in the treatment of renal ischemic injury.
本研究探讨了丹参乙醇提取物（SMEE）预处理对肾缺血再灌注（IR）大鼠肾功能标志物、免疫和抗氧化活性的影响。将 Wistar 大鼠肾脏在 37°C 下进行 60 分钟的整体缺血，然后再进行 30 分钟的再灌注，并将其随机分为假手术组、IR 模型组和 3 个 SMEE 处理组（每组 n = 8）。结果表明，与假手术组相比，IR 大鼠的血清肌酐（Scr）、血尿素氮（BUN）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和丙二醛（MDA）水平较高，抗氧化酶活性较低。在 IR 手术前用丹参乙醇提取物预处理 20 天可改善肾功能，减轻 IR 引起的肾炎症和氧化损伤。结论：丹参乙醇提取物可能有益于治疗肾缺血损伤。
