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Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.

作者信息

Lin Fu-Yang, Zhang Yonghui, Hensler Mary, Liu Yi-Liang, Chow Ohn A, Zhu Wei, Wang Ke, Pang Ran, Thienphrapa Wdee, Nizet Victor, Oldfield Eric

机构信息

Center for Biophysics & Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL 61801, USA.

出版信息

ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002/cmdc.201100589. Epub 2012 Jan 30.

DOI:10.1002/cmdc.201100589
PMID:22290830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3471559/
Abstract
摘要

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本文引用的文献

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Mechanism of action and inhibition of dehydrosqualene synthase.脱水鲨烯合酶的作用机制和抑制作用。
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21337-42. doi: 10.1073/pnas.1010907107. Epub 2010 Nov 23.
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Statins enhance formation of phagocyte extracellular traps.他汀类药物增强吞噬细胞细胞外陷阱的形成。
Cell Host Microbe. 2010 Nov 18;8(5):445-54. doi: 10.1016/j.chom.2010.10.005.
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Antibiotics for emerging pathogens.针对新出现病原体的抗生素。
一种真菌角鲨烯合酶的结构与生物信息学研究以及与其他膜蛋白的比较
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Innate Immune Response against Preincubated with Subinhibitory Concentration of -Anethole.预先孵育亚抑菌浓度 - 茴香脑的先天免疫反应。
Int J Mol Sci. 2020 Jun 11;21(11):4178. doi: 10.3390/ijms21114178.
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The role of the innate immune system on pulmonary infections.固有免疫系统在肺部感染中的作用。
Biol Chem. 2019 Mar 26;400(4):443-456. doi: 10.1515/hsz-2018-0304.
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Structural and Chemical Biology of Terpenoid Cyclases.萜类环化酶的结构与化学生物学
Chem Rev. 2017 Sep 13;117(17):11570-11648. doi: 10.1021/acs.chemrev.7b00287. Epub 2017 Aug 25.
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Curr Drug Targets. 2018;19(2):111-127. doi: 10.2174/1389450117666161128123536.
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Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.金黄色葡萄球菌七烯基二磷酸合酶的结构、功能与抑制。
ChemMedChem. 2016 Sep 6;11(17):1915-23. doi: 10.1002/cmdc.201600311. Epub 2016 Jul 26.
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Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus.金黄色葡萄球菌II类3-羟基-3-甲基戊二酰辅酶A还原酶的必需性、表达及特性
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