HPRU, The Robens Instatute, University of Surrey, Milford Hospital, Godalming, Surrey GU7 1 UF, UK.
J Psychopharmacol. 1992 Jan;6(2):198-203. doi: 10.1177/026988119200600212.
The psychopharmacological profiles of 15 psychotropic drugs used as antidepressants are reviewed, and their relative behavioural toxicity ratings are compared. The pharmacodynamic activity of these drugs was assessed using a standardized test battery which included critical flicker fusion threshold (CFF), choice reaction time (CRT), tracking and subjective rating scales. It is reported that there is a wide range of behavioural toxicity exhibited by these compounds, although there is little measurable difference in their clinical efficacy. Drugs which have low behavioural toxicity should therefore be preferred as they are less disruptive of patients' everyday activities, produce better quality of life and are not counter-therapeutic.
本文综述了 15 种作为抗抑郁药使用的精神药物的精神药理学特征，并对其相对行为毒性进行了比较。这些药物的药效学活性采用标准化测试电池进行评估，包括临界闪烁融合阈值（CFF）、选择反应时间（CRT）、跟踪和主观评分量表。据报道，这些化合物表现出广泛的行为毒性，尽管它们的临床疗效几乎没有差异。因此，应优先选择行为毒性低的药物，因为它们对患者的日常活动干扰较小，生活质量更好，且不会产生反治疗作用。
