Wu Kenneth K, Huan Youming
Merck Research Laboratories, Rahway, New Jersey, USA.
Curr Protoc Pharmacol. 2008 Mar;Chapter 5:Unit 5.47. doi: 10.1002/0471141755.ph0547s40.
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options.
链脲佐菌素（STZ）是一种可导致胰腺β细胞破坏的抗生素，因此在实验中被广泛用作能够诱发胰岛素依赖型糖尿病（IDDM）的药物，IDDM也被称为1型糖尿病（T1DM）。本单元描述了使用STZ在小鼠和大鼠中诱导胰岛素缺乏和高血糖的实验方案。这些糖尿病模型可用于评估T1DM的发病机制、筛选治疗该疾病的潜在疗法以及评估治疗方案。
