Liu Yiqun, Yang Li, Cui Yue
School of Materials Science and Engineering, Peking University, Beijing, 100871 China.
Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034 China.
Microsyst Nanoeng. 2024 Aug 19;10(1):112. doi: 10.1038/s41378-024-00663-y. eCollection 2024.
The development of a wearable, easy-to-fabricate, and stable intelligent minisystem is highly desired for the closed-loop management of diabetes. Conventional systems always suffer from large size, high cost, low stability, or complex fabrication. Here, we show for the first time a wearable, rapidly manufacturable, stability-enhancing microneedle patch for diabetes management. The patch consists of a graphene composite ink-printed sensor on hollow microneedles, a polyethylene glycol (PEG)-functionalized electroosmotic micropump integrated with the microneedles, and a printed circuit board for precise and intelligent control of the sensor and pump to detect interstitial glucose and deliver insulin through the hollow channels. Via synthesizing and printing the graphene composite ink, the sensor fabrication process is fast and the sensing electrodes are stable. The PEG functionalization enables the micropump a significantly higher stability in delivering insulin, extending its lifetime from days to weeks. The patch successfully demonstrated excellent blood glucose control in diabetic rats. This work may introduce a new paradigm for building new closed-loop systems and shows great promise for widespread use in patients with diabetes.
对于糖尿病的闭环管理而言，非常需要开发一种可穿戴、易于制造且稳定的智能微型系统。传统系统总是存在体积大、成本高、稳定性低或制造复杂等问题。在此，我们首次展示了一种用于糖尿病管理的可穿戴、可快速制造、稳定性增强的微针贴片。该贴片由空心微针上的石墨烯复合墨水印刷传感器、与微针集成的聚乙二醇（PEG）功能化电渗微泵以及用于精确和智能控制传感器和泵以检测间质葡萄糖并通过空心通道输送胰岛素的印刷电路板组成。通过合成和印刷石墨烯复合墨水，传感器制造过程快速且传感电极稳定。PEG功能化使微泵在输送胰岛素时具有显著更高的稳定性，将其使用寿命从数天延长至数周。该贴片在糖尿病大鼠中成功展示了出色的血糖控制效果。这项工作可能会为构建新的闭环系统引入一种新范式，并在糖尿病患者中广泛应用展现出巨大潜力。
