链脲佐菌素诱导的小鼠和大鼠糖尿病模型。
Streptozotocin-Induced Diabetic Models in Mice and Rats.
作者信息
Furman Brian L
机构信息
Strathclyde Institute of Pharmacy & Biomedical Sciences, Glasgow, Scotland, United Kingdom.
出版信息
Curr Protoc Pharmacol. 2015 Sep 1;70:5.47.1-5.47.20. doi: 10.1002/0471141755.ph0547s70.
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
链脲佐菌素（STZ）是一种可导致胰岛β细胞破坏的抗生素，在实验中被广泛用于建立1型糖尿病（T1DM）模型。本单元详细介绍了在小鼠和大鼠中诱导STZ引起胰岛素缺乏和高血糖的实验方案。还描述了使用STZ建立2型糖尿病动物模型的方案。这些动物用于评估糖尿病的病理后果以及筛选治疗该疾病的潜在疗法。
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