Waldner Maximilian J, Neurath Markus F
Institute of Molecular Medicine, University of Mainz, Mainz, Germany.
Curr Protoc Pharmacol. 2009 Sep;Chapter 5:Unit 5.55. doi: 10.1002/0471141755.ph0555s46.
Crohn's disease (CD) and ulcerative colitis (UC), both of which are referred to as inflammatory bowel disease (IBD), are chronic inflammatory disorders of the gastrointestinal tract that have characteristic clinical, pathological, endoscopic, and radiologic features. Knowledge about the pathogenesis of IBD has dramatically increased in recent years based in part on the use of experimental models of IBD. Although none of these models exactly mimics the human disorder, they have proven to be useful for studying many important aspects of these conditions. Detailed in this unit is a description of the most commonly used chemically induced mouse models of IBD. These include trinitrobenzene sulfonic acid (TNBS), oxazolone, and acute or chronic dextran sodium sulfate (DSS) colitis models.
克罗恩病（CD）和溃疡性结肠炎（UC），两者均被称为炎症性肠病（IBD），是胃肠道的慢性炎症性疾病，具有特征性的临床、病理、内镜和放射学特征。近年来，部分基于IBD实验模型的应用，关于IBD发病机制的知识有了显著增加。尽管这些模型均不能完全模拟人类疾病，但已证明它们对于研究这些疾病的许多重要方面是有用的。本单元详细描述了最常用的化学诱导性IBD小鼠模型。这些模型包括三硝基苯磺酸（TNBS）、恶唑酮，以及急性或慢性葡聚糖硫酸钠（DSS）结肠炎模型。
