Medical Radiation Physics, Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital Malmö, Sweden.
Magn Reson Med. 2012 Dec;68(6):1894-9. doi: 10.1002/mrm.24183. Epub 2012 Jan 31.
The conversion of hyperpolarized (13)C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13)C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13)C(1)-pyruvate. Using cardiac gating, it was possible to acquire (13)C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism.
将（13）C 标记的丙酮酸转化为克雷布斯循环中的代谢产物，为心肌的代谢状态和活力提供了有价值的信息。因此，成像方法必须能够在谱上区分不同的（13）C 代谢物。然而，对光谱选择性的要求与心脏成像中对快速图像采集和高空间分辨率的要求相冲突。在这项工作中，研究了在注射（13）C（1）-丙酮酸后猪心的低翻转角平衡稳态自由进动序列的可行性。使用心脏门控，可以在单个心跳内采集（13）C 碳酸氢盐图像（采集时间为 150ms），而不会破坏来自（13）C 标记的丙酮酸的底物信号。因此，该技术可能对心脏代谢的动态研究有用。
