University of Michigan Department of Psychiatry, Sleep & Chronophysiology Laboratory, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109-2700, USA.
Sleep. 2012 Feb 1;35(2):273-8. doi: 10.5665/sleep.1638.
This study evaluated slow wave activity homeostatic response to a mild sleep challenge in alcohol-dependent adults compared to healthy controls.
Participants maintained a 23:00-06:00 schedule for 5 days verified by actigraphy and diary, followed by 3 nights in the lab: adaptation, baseline, and a sleep delay night with an 02:00-09:00 schedule.
Sleep ' Chronophysiology laboratory.
48 alcohol-dependent adults (39 men, 9 women) who were abstinent for at least 3 weeks and 16 healthy control adults (13 men, 3 women), 21-55 years of age participated in study.
N/A.
Slow wave EEG activity (SWA) in consecutive NREM periods was compared between baseline and sleep delay nights and between AD and HC groups, using age and sex as statistical covariates. The AD group showed a blunted SWA response to sleep delay with significantly lower SWA power than the HC group. Exponential regression analyses confirmed lower asymptotic SWA with a slower decay rate over NREM sleep time in the AD group. Results were similar for raw SWA and %SWA on the delay night expressed relative to baseline SWA.
Alcohol dependence is associated with impaired SWA regulation and a blunted response to a mild homeostatic sleep challenge.
本研究评估了酒精依赖成年人与健康对照组相比，对轻度睡眠挑战的慢波活动稳态反应。
参与者按照活动记录仪和日记记录的 23:00-06:00 时间表维持 5 天，然后在实验室进行 3 个晚上的适应、基线和睡眠延迟，时间表为 02:00-09:00。
睡眠“生物钟生理学实验室”。
48 名酒精依赖成年人（39 名男性，9 名女性），至少戒酒 3 周，16 名健康对照组成年人（13 名男性，3 名女性），年龄在 21-55 岁之间参加了研究。
无。
使用年龄和性别作为统计协变量，比较基线和睡眠延迟夜间以及 AD 和 HC 组之间连续 NREM 期的慢波 EEG 活动（SWA）。与 HC 组相比，AD 组对睡眠延迟的 SWA 反应迟钝，SWA 功率明显较低。指数回归分析证实，AD 组在 NREM 睡眠期间 SWA 的渐近值较低，衰减率较慢。在延迟夜间相对于基线 SWA 表达的原始 SWA 和 %SWA 上，结果相似。
酒精依赖与 SWA 调节受损和对轻度稳态睡眠挑战的反应迟钝有关。
