Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Rd, Oxford OX1 3TA, UK.
Sensors (Basel). 2010;10(3):1765-81. doi: 10.3390/s100301765. Epub 2010 Mar 3.
Whispering gallery mode resonances in liquid droplets and microspheres have attracted considerable attention due to their potential uses in a range of sensing and technological applications. We describe a whispering gallery mode sensor in which standard optical fibre is used as the whispering gallery mode resonator. The sensor is characterised in terms of the response of the whispering gallery mode spectrum to changes in resonator size, refractive index of the surrounding medium, and temperature, and its measurement capabilities are demonstrated through application to high-precision fibre geometry profiling and the detection of unlabelled biochemical species. The prototype sensor is capable of detecting unlabelled biomolecular species in attomole quantities.
由于 whispering gallery mode resonances 在液滴和微球中的潜在应用,它们引起了相当大的关注,这些应用涵盖了一系列传感和技术领域。我们描述了一种 whispering gallery mode 传感器,其中标准光纤被用作 whispering gallery mode 谐振器。该传感器的特点在于 whispering gallery mode 光谱对谐振器尺寸、周围介质折射率和温度变化的响应,并通过应用于高精度光纤几何形状轮廓和未标记生化物质的检测来展示其测量能力。该原型传感器能够检测到皮摩尔数量的未标记生物分子物种。