Eljabu W, Finch G, Nottingham J, Vaingankar N
Departments of Plastic and Reconstructive Surgery, General Surgery, and Histopathology, Northampton General Hospital, Northampton NN1 5BD, UK.
Int J Breast Cancer. 2011;2011:413949. doi: 10.4061/2011/413949. Epub 2011 Jul 26.
Breast cancer is the most frequent malignancy in women accounting for approximately 32% of all cancers, with a lifetime risk of 1 in 10. It causes considerable morbidity and mortality. Recently, the survival rate has dramatically increased due to early detection of the disease and improvement in the treatment measures. However, more than 30% of the patients develop metastatic diseases following surgical treatment, radiotherapy, hormonal therapy, or chemotherapy. Distant spread is usually found in bones, lungs, liver, brain and skin. Rarely, it spreads to bowel, spleen, gallbladder, pancreas, urinary bladder, and eyes. Breast cancer is the second commonest primary tumour responsible for gastrointestinal metastases after malignant melanoma. We report a case of a Caucasian female who developed an intestinal obstruction secondary to metastatic deposits to the small bowel and later to the rectum from breast lobular carcinoma 2 years after mastectomy, axillary clearance, radiotherapy, hormonal therapy, and transverse rectus abdominis myocutaneous (TRAM) flap for reconstruction.
乳腺癌是女性中最常见的恶性肿瘤,约占所有癌症的32%,终生患病风险为十分之一。它会导致相当高的发病率和死亡率。近年来,由于疾病的早期发现和治疗措施的改进,生存率显著提高。然而,超过30%的患者在接受手术治疗、放疗、激素治疗或化疗后会发生转移性疾病。远处转移通常发生在骨骼、肺部、肝脏、大脑和皮肤。很少会转移到肠道、脾脏、胆囊、胰腺、膀胱和眼睛。乳腺癌是继恶性黑色素瘤之后导致胃肠道转移的第二常见原发性肿瘤。我们报告一例白人女性病例,该患者在乳房切除、腋窝清扫、放疗、激素治疗以及采用腹直肌肌皮瓣(TRAM)进行重建两年后,发生小肠转移性沉积物继发肠梗阻,随后直肠也出现转移,原发肿瘤为乳腺小叶癌。