槐耳的抗癌作用与P53的下调有关。
Anticancer effects of Huaier are associated with down-regulation of P53.
作者信息
Xu Xiao, Wei Qiang, Wang Kai, Ling Qi, Xie Haiyang, Zhou Lin, Zheng Shusen
机构信息
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Asian Pac J Cancer Prev. 2011;12(9):2251-4.
This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.
本研究旨在探讨槐耳对实验性肝细胞癌（HCC）发生发展的抗癌作用机制。将75只大鼠分为5组，分别给予N-亚硝基二乙胺（B、C、D和E组）或生理盐水（A组）。C组和E组大鼠还给予槐耳。在第15周处死时，C组的HCC发生率低于与血清甲胎蛋白相关的组。B组的血清谷丙转氨酶浓度（高98.9%）和P53 mRNA水平（高23.2%）高于C组。D组和E组的长期生存率无显著差异。槐耳可保护肝脏免受化学损伤，并进一步抑制HCC的发展，可能与下调P53有关。
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