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本文引用的文献

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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.全球癌症发病与死亡：GLOBOCAN 2012 数据源、方法与主要模式。
Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9.
2
Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling.槐耳清膏通过抑制雌激素受体α信号通路抑制人乳腺癌细胞增殖。
Int J Oncol. 2013 Jul;43(1):321-8. doi: 10.3892/ijo.2013.1947. Epub 2013 May 20.
3
Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.槐耳清膏通过 AKT/GSK3β/β-catenin 通路抑制卵巢癌细胞迁移。
PLoS One. 2013 May 8;8(5):e63731. doi: 10.1371/journal.pone.0063731. Print 2013.
4
Effects of Huaier aqueous extract on proliferation and apoptosis in the melanoma cell line A875.槐耳清膏对黑素瘤细胞株 A875 增殖和凋亡的影响。
Acta Histochem. 2013 Sep;115(7):705-11. doi: 10.1016/j.acthis.2013.02.010. Epub 2013 Apr 16.
5
Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/β-catenin pathway.槐耳水提取物通过下调Wnt/β-连环蛋白信号通路部分抑制结直肠癌干细胞生长。
Oncol Lett. 2013 Apr;5(4):1171-1176. doi: 10.3892/ol.2013.1145. Epub 2013 Jan 21.
6
A polysaccharide from the fungi of Huaier exhibits anti-tumor potential and immunomodulatory effects.华鹅膏菌多糖具有抗肿瘤潜力和免疫调节作用。
Carbohydr Polym. 2013 Jan 30;92(1):577-82. doi: 10.1016/j.carbpol.2012.09.006. Epub 2012 Sep 13.
7
Anticancer effects of Huaier are associated with down-regulation of P53.槐耳的抗癌作用与P53的下调有关。
Asian Pac J Cancer Prev. 2011;12(9):2251-4.
8
Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).PI3K/PTEN/AKT 通路中的基因改变作为耐药机制（综述）。
Int J Oncol. 2012 Mar;40(3):639-44. doi: 10.3892/ijo.2011.1312. Epub 2011 Dec 20.
9
Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis.槐耳清膏通过诱导细胞凋亡抑制乳腺癌细胞增殖。
Cancer Sci. 2010 Nov;101(11):2375-83. doi: 10.1111/j.1349-7006.2010.01680.x.
10
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.细胞凋亡与自噬：caspase-9的磷酸化调控
FEBS J. 2009 Nov;276(21):6063-73. doi: 10.1111/j.1742-4658.2009.07330.x. Epub 2009 Sep 29.

槐耳通过调节PI3K/AKT信号通路对人胃癌细胞增殖和凋亡的影响。

Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.

作者信息

Xie Hua-Xia, Xu Zhi-Yuan, Tang Jia-Ning, DU Yi-An, Huang Ling, Yu Peng-Fei, Cheng Xiang-Dong

机构信息

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.

Department of Abdominal Surgery, Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China.

出版信息

Exp Ther Med. 2015 Sep;10(3):1212-1218. doi: 10.3892/etm.2015.2600. Epub 2015 Jun 29.

DOI:10.3892/etm.2015.2600
PMID:26622467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4533155/
Abstract

The aim of the present study was to investigate the effect of Huaier on the proliferation and apoptosis of the MKN45 and SGC7901 gastric cancer cell lines. The MTT assay was used to measure the effects of Huaier on the growth of the cells, while cell cycle distribution and apoptosis levels were analyzed using flow cytometry. Western blotting was used to assess the levels of proteins associated with the apoptotic pathway. It was found that cell survival decreased with the increase in the concentration of Huaier, and the apoptosis rates were increased in a dose-dependent manner both in MKN45 and SGC7901 cells. The number of cells in the G2/M phase in the Huaier-treated groups was increased in a dose-dependent manner compared with that in the control group. Huaier inhibited phosphorylated- (p-)AKT1, phosphatidylinositol 3-kinase (PI3K), pyruvate dehydrogenase kinase isoform 1, p-phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase and B-cell lymphoma 2 expression and upregulated cleaved-caspase-9 expression in a dose-dependent manner. In conclusion, Huaier can strongly inhibit gastric cancer cell proliferation by inhibiting cyclin B1 expression, promoting G2/M-phase arrest and modulating the PI3K/AKT signaling pathway, and can induce gastric cancer cell apoptosis by modulating the PI3K/AKT signaling pathway in dose-dependent manner.

摘要

本研究的目的是探讨槐耳对MKN45和SGC7901胃癌细胞系增殖和凋亡的影响。采用MTT法检测槐耳对细胞生长的影响，同时利用流式细胞术分析细胞周期分布和凋亡水平。采用蛋白质印迹法评估与凋亡途径相关的蛋白质水平。结果发现，随着槐耳浓度的增加，细胞存活率降低，MKN45和SGC7901细胞的凋亡率均呈剂量依赖性增加。与对照组相比，槐耳处理组G2/M期细胞数量呈剂量依赖性增加。槐耳抑制磷酸化（p-）AKT1、磷脂酰肌醇3激酶（PI3K）、丙酮酸脱氢酶激酶同工型1、p-磷脂酰肌醇3,4,5-三磷酸3-磷酸酶和双特异性蛋白磷酸酶以及B细胞淋巴瘤2的表达，并呈剂量依赖性上调裂解的半胱天冬酶-9的表达。综上所述，槐耳可通过抑制细胞周期蛋白B1表达、促进G2/M期阻滞和调节PI3K/AKT信号通路来强烈抑制胃癌细胞增殖，并可通过剂量依赖性方式调节PI3K/AKT信号通路诱导胃癌细胞凋亡。