Tahaei Seyed Mohammad Ebrahim, Mohebbi Seyed Reza, Fatemi Seyed Reza, Mohammadi Parvaneh, Malek Fatemeh Nemati, Azimzadeh Pedram, Almasi Shohreh, Mirsattari Dariush, Zali Mohammad Reza
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asian Pac J Cancer Prev. 2011;12(9):2447-50.
There is some evidence that human T-cell lymphotropic virus (HTLV-1) infection has a reverse association with gastric cancer (GC). Data about this association in the Iranian population are scarce. In this study we therefore assessed the frequency of anti-HTLV-1 antibody in GC patients and compare it to antibody presence in healthy individuals in Iranian population. This case control study was performed between 2008-2011 on 201 GC patients and 219 control subjects. HTLV-1 antibodies were assessed by ELISA and the positive results were confirmed by western blotting. Totals of 201 gastric cancer patients and 219 controls were enrolled in this study. The tumors in the majority of patients (45.3%) were in the distal (non-cardia) area. Mean age of patients at the time of diagnosis was 59.2±12.5 and mean age of controls was 57.7±11.3. While only one GC patient (0.5%) was positive for HTLV-1 antibody, there were four individuals (1.89%) from the control group with antibodies. In addition, smoking had statistically significant relationship with cancer (P=0.001). Our study showed that the frequency of HTLV-1 antibody in patients was lower than in controls, similar to the results obtained in Japan. Further investigations with a larger sample size are needed in order to determine the association between GC and HTLV-1 infection in Iran.
有证据表明，人类嗜T细胞病毒1型（HTLV-1）感染与胃癌（GC）呈负相关。关于伊朗人群中这种关联的数据很少。因此，在本研究中，我们评估了伊朗人群中胃癌患者抗HTLV-1抗体的频率，并将其与健康个体中抗体的存在情况进行比较。这项病例对照研究于2008年至2011年期间对201例胃癌患者和219名对照者进行。通过酶联免疫吸附测定（ELISA）评估HTLV-1抗体，并通过蛋白质印迹法确认阳性结果。本研究共纳入201例胃癌患者和219名对照者。大多数患者（45.3%）的肿瘤位于远端（非贲门）区域。患者诊断时的平均年龄为59.2±12.5岁，对照者的平均年龄为57.7±11.3岁。虽然只有1例胃癌患者（0.5%）HTLV-1抗体呈阳性，但对照组中有4人（1.89%）有抗体。此外，吸烟与癌症有统计学显著关系（P=0.001）。我们的研究表明，患者中HTLV-1抗体的频率低于对照者，这与在日本获得的结果相似。为了确定伊朗胃癌与HTLV-1感染之间的关联，需要进行更大样本量的进一步研究。
