Kato H, Hamada T, Tsuji T, Baba T, Seki J, Kobayashi Y
Department of Dermatology, Osaka City University Medical School, Japan.
J Dermatol. 1990 Jul;17(7):414-22. doi: 10.1111/j.1346-8138.1990.tb01668.x.
A patient with diabetes mellitus who developed the typical classic lesions of Kaposi's sarcoma is described. Our patient presented with a reddish-purple papulonodular lesion on the right foot of five months' duration. A skin biopsy specimen showed a proliferation of spindle cells forming numerous vascular slits and a diffuse extravasation of erythrocytes. The patient's sera was negative for human immunodeficiency virus (HIV) antibodies and cytomegalovirus (CMV) antibodies. Ultrastructural examination demonstrated fibroblast-like spindle cells phagocytosing and digesting red blood cells to form vascular spaces. The patient died, due to gastrointestinal hemorrhage, and the autopsy revealed an extensive visceral involvement of Kaposi's sarcoma.
本文描述了一位患有糖尿病且出现典型卡波西肉瘤经典病变的患者。我们的患者右脚出现一个红紫色丘疹结节性病变，持续了五个月。皮肤活检标本显示梭形细胞增殖，形成许多血管裂隙，并有红细胞弥漫性外渗。患者血清中人类免疫缺陷病毒（HIV）抗体和巨细胞病毒（CMV）抗体均为阴性。超微结构检查显示成纤维细胞样梭形细胞吞噬和消化红细胞以形成血管腔隙。患者因胃肠道出血死亡，尸检显示卡波西肉瘤广泛累及内脏。
