School of Public Health, Anhui Medical University, Hefei, China.
Neoplasma. 2012;59(3):289-96. doi: 10.4149/neo_2012_037.
Results from published studies on the association of Human Oxoguanine Glycosylase 1 (hOGG1) S326C genetic polymorphism with the risk of gastric cancer are inconsistent. We performed a meta-analysis to summarize the possible association. Eleven case-control studies including 2168 cases and 4058 controls were identified from electronic databases (Pubmed, Elsevier Science Direct, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and the Chinese database, Wanfang). No significant association between hOGG1 S326C genetic polymorphism and risk of gastric cancer was observed in the overall analysis. In the stratified analysis based on ethnicity, still no significant association was observed in Europeans, Asians, or Brazilians. This meta-analysis provided evidence that hOGG1 S326C genetic polymorphism was not associated with increased risk of gastric cancer. However, additional studies with large sample size and better study designs are warranted to verify our finding.
已发表的关于人类 8-氧鸟嘌呤糖苷酶 1（hOGG1）S326C 遗传多态性与胃癌风险关联的研究结果不一致。我们进行了荟萃分析以总结可能的关联。从电子数据库（Pubmed、Elsevier Science Direct、中国国家知识基础设施（CNKI）、中国生物医学文献数据库（CBM）和中国数据库 Wanfang）中确定了 11 项病例对照研究，包括 2168 例病例和 4058 例对照。总体分析显示，hOGG1 S326C 遗传多态性与胃癌风险之间无显著关联。根据种族进行分层分析时，在欧洲人、亚洲人和巴西人中也未观察到显著关联。这项荟萃分析提供的证据表明，hOGG1 S326C 遗传多态性与胃癌风险增加无关。然而，需要更多具有更大样本量和更好研究设计的研究来验证我们的发现。
