Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb, Croatia.
Res Vet Sci. 2012 Oct;93(2):918-20. doi: 10.1016/j.rvsc.2012.01.008. Epub 2012 Jan 31.
Biochemical markers of bone turnover have been shown to be useful as inexpensive and noninvasive tools for monitoring skeletal health. The reference range for bone markers in dogs has been set by different age groups. However, other sources of biological variations were not fully investigated in dogs. To explore whether sex influences the interpretation of bone marker data we examined serum bone markers in 33 male and 25 female dogs. The bone markers selected for this study were: bone alkaline phosphatase (BALP) and osteocalcin (OC) as indicators of bone formation, and C-terminal telopeptide (CTx) of type I collagen as marker of bone resorption. All concentrations of bone markers were lower, but still within the reference range reported for dogs. We found statistically significant differences of the median OC and CTx serum concentrations between males and females. The results of this study suggest that there are sex differences in biochemical markers of bone turnover in dogs which should be considered in interpretation of bone marker data.
骨转换的生化标志物已被证明是一种有用的工具，可用于监测骨骼健康，其价格低廉且无创伤。犬类的骨标志物参考范围已按不同年龄段设定。然而，犬类中其他来源的生物学差异尚未得到充分研究。为了探究性别是否会影响对骨标志物数据的解读，我们检测了 33 只雄性犬和 25 只雌性犬的血清骨标志物。本研究选择的骨标志物有：骨碱性磷酸酶（BALP）和骨钙素（OC），作为骨形成的指标，以及 I 型胶原 C 端肽（CTX），作为骨吸收的标志物。所有骨标志物的浓度均较低，但仍在犬类报告的参考范围内。我们发现雄性犬和雌性犬之间的 OC 和 CTx 血清浓度中位数存在统计学显著差异。本研究结果表明，犬类的骨转换生化标志物存在性别差异，在解读骨标志物数据时应予以考虑。
