Kim J Y, Germolec D R, Luster M I
Immunotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Immunopharmacol Immunotoxicol. 1990;12(2):257-76. doi: 10.3109/08923979009019672.
There has been continuing interest in the development of synthetic and natural compounds which modify the immune response, particularly for the treatment of AIDS and cancer. Panax ginseng, employed for its putative medicinal properties in South Asia, was examined for its immunomodulatory properties in mice. A systematic evaluation of multiple immune system components revealed that Panax ginseng stimulated basal natural killer (NK) cell activity following subchronic exposure and helped stimulate recovery of NK function in cyclophosphamide-immunosuppressed mice but did not further stimulate NK activity in poly I:C treated mice. Other immunological parameters examined, including T and B cell responses were not affected. Panax ginseng provided a degree of protection against infection with L. monocytes but did not inhibit the growth of transplanted syngeneic tumor cells. Increased resistance to L. monocytogenes was not detected in challenged mice previously given immunosuppressive doses of cyclophosphamide. Taken together, these data suggest that Panax ginseng has some immunomodulatory properties, primarily associated with NK cell activity.
人们一直对开发能够调节免疫反应的合成化合物和天然化合物有着持续的兴趣，特别是用于治疗艾滋病和癌症。在南亚因其假定的药用特性而被使用的人参，在小鼠中对其免疫调节特性进行了研究。对多个免疫系统成分的系统评估显示，亚慢性暴露后人参刺激了基础自然杀伤（NK）细胞活性，并有助于刺激环磷酰胺免疫抑制小鼠的NK功能恢复，但在聚肌胞苷酸（poly I:C）处理的小鼠中并未进一步刺激NK活性。所检测的其他免疫参数，包括T细胞和B细胞反应均未受到影响。人参对单核细胞李氏菌感染提供了一定程度的保护，但并未抑制同基因移植肿瘤细胞的生长。在先前给予免疫抑制剂量环磷酰胺的受攻击小鼠中未检测到对单核细胞李氏菌的抵抗力增强。综上所述，这些数据表明人参具有一些免疫调节特性，主要与NK细胞活性相关。
