Salim Rehana, Nehvi Iqra Bashir, Mir Rakeeb Ahmad, Tyagi Anshika, Ali Sajad, Bhat Owais M
Division of Food Science and Technology, SKUAST, Shalimar, India.
Sheri Kashmir Institute of Medical Sciences, Srinagar, India.
Front Nutr. 2023 Aug 31;10:1215873. doi: 10.3389/fnut.2023.1215873. eCollection 2023.
Humans are constantly facing multiple health challenges from both communicable and non-communicable diseases that significantly affect their health. Additionally, drug resistance or failure has made the situation even worse and poses serious challenges for researchers to develop new drugs. Hence, to address these problems, there is an urgent need to discover and develop timely and long-term-based therapeutic treatments from different sources. One such approach is harnessing the potential of plant secondary metabolites. Plants have been utilized for therapeutic purposes in addition to being used for nutritional benefits. In the last two decades, plant-based drug developments have been one of the effective means of treating human diseases owing to their multiple functions. More recently, anti-nutritional factors (ANFs) have emerged as one of the important targets for novel plant-based drug development due to their multifaceted and potential pharmacological properties. However, their anti-nutritional properties have been the major setback for their limited success in the pharmacological sector. In this review, we provide an overview of ANFs and their beneficial roles in preventing human diseases with multiple case studies. We also highlight the recent developments and applications of ANFs in the food industry, agriculture, and pharmaceutics with future perspectives. Furthermore, we evaluate meta-analyses on ANFs from the last 30 years in relation to their function in human health benefits. This review is an endeavor to reevaluate the merit of these natural compounds and explore their potential for both human and animal health.
人类不断面临来自传染病和非传染病的多重健康挑战，这些挑战严重影响他们的健康。此外，耐药性或药物失效使情况更加糟糕，给研究人员开发新药带来了严峻挑战。因此，为了解决这些问题，迫切需要从不同来源发现并开发及时且基于长期的治疗方法。一种这样的方法是利用植物次生代谢产物的潜力。植物除了具有营养益处外，还一直被用于治疗目的。在过去二十年中，基于植物的药物开发因其多种功能一直是治疗人类疾病的有效手段之一。最近，抗营养因子（ANFs）因其多方面的潜在药理特性，已成为新型基于植物的药物开发的重要靶点之一。然而，它们的抗营养特性一直是其在药理学领域取得有限成功的主要障碍。在这篇综述中，我们通过多个案例研究概述了抗营养因子及其在预防人类疾病中的有益作用。我们还强调了抗营养因子在食品工业、农业和制药领域的最新进展和应用，并展望了未来前景。此外，我们评估了过去30年关于抗营养因子对人类健康益处作用的荟萃分析。这篇综述旨在重新评估这些天然化合物的价值，并探索它们对人类和动物健康的潜力。
