Ługowski Mateusz, Saczko Jolanta, Kulbacka Julita, Banaś Teresa
Akademia Medyczna we Wrocławiu, Katedra i Zakład Biochemii Lekarskiej.
Pol Merkur Lekarski. 2011 Nov;31(185):313-7.
Reactive oxygen and nitrogen species (ROS and RNS respectively) play an important role in the proper functioning of many cellular processes. Generation of reactive oxygen species is an integral part of aerobic metabolism of cells. Their overproduction and subsequent oxidative stress occurs during pathogenesis of many diseases. Nitrosative stress is very closely linked to oxidative stress. Nitric oxide (NO), can react with molecular oxygen, superoxide anions and metal cations generating consecutive reactive oxygen species. These highly reactive chemical compounds react with proteins impairing their function by oxidation, or nitrosylation of amino acid residues, which may induce apoptosis. Furthermore, nitric oxide enhances the effect induced by cyclooxygenases and becomes a mediator of the inflammatory response. This paper gathers key information on the reactive oxygen and nitrogen species as well as processes in which they participate.
活性氧和活性氮（分别为ROS和RNS）在许多细胞过程的正常运作中发挥着重要作用。活性氧的产生是细胞有氧代谢不可或缺的一部分。在许多疾病的发病过程中会出现它们的过量产生及随后的氧化应激。亚硝化应激与氧化应激密切相关。一氧化氮（NO）可与分子氧、超氧阴离子和金属阳离子反应，生成一系列活性氧。这些高反应性的化合物与蛋白质反应，通过氧化或氨基酸残基的亚硝基化损害其功能，这可能诱导细胞凋亡。此外，一氧化氮增强环氧化酶诱导的效应，并成为炎症反应的介质。本文收集了有关活性氧和活性氮及其参与过程的关键信息。
