Cbl 暴露出其 RING 指。
Cbl exposes its RING finger.
出版信息
Nat Struct Mol Biol. 2012 Feb 3;19(2):131-3. doi: 10.1038/nsmb.2241.
Abstract
The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restricted to specific substrates.
摘要
Cbl 家族的 RING 指泛素连接酶调节着许多系统中的信号转导。两项新的研究为 Cbl 蛋白中特定酪氨酸的磷酸化如何增强其泛素连接酶活性提供了结构基础，深入了解了 Cbl 蛋白的泛素化如何限制在特定底物上。
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本文引用的文献
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