Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Office 2433, Ann Arbor, MI 48109-2700, USA.
Behav Genet. 2012 Jul;42(4):603-13. doi: 10.1007/s10519-012-9525-2.
Bulimic behaviors are frequently associated with alcohol use disorders. However, extant family and twin study findings have been inconsistent with regard to whether these behaviors share etiologic influences. A sample of 292 young adult, female twins was used to examine genetic and environmental factors underlying the association between binge eating and compensatory behaviors (e.g., vomiting)and alcohol use. Binge eating and compensatory behaviors were assessed using the Minnesota Eating Behavior Survey.Alcohol use was measured using the Alcohol Use Disorders Identification Test. Univariate models indicated that the heritability of binge eating, compensatory behaviors, and alcohol use was 41, 28, and 78%, respectively, with the remaining variance due to nonshared environmental effects.Bivariate models indicated that there was a moderate-to-large degree of overlap (genetic correlation = 0.31–0.61) in additive genetic factors between alcohol use and binge eating and compensatory behaviors, and no overlap in environmental effects. Findings suggest that these phenotypes co-aggregate in families and that similar genes or heritable traits may be contributing to their co-occurrence.
贪食行为常与酒精使用障碍有关。然而，现有的家庭和双胞胎研究结果在这些行为是否具有共同的病因影响方面存在不一致。本研究使用了 292 名年轻成年女性双胞胎样本，旨在探讨暴食和补偿行为（如呕吐）与酒精使用之间的关联的遗传和环境因素。使用明尼苏达饮食行为调查评估暴食和补偿行为。使用酒精使用障碍识别测试测量酒精使用。单变量模型表明，暴食、补偿行为和酒精使用的遗传率分别为 41%、28%和 78%，其余差异由非共享环境效应引起。双变量模型表明，酒精使用和暴食及补偿行为之间的加性遗传因素存在中度到高度的重叠（遗传相关系数为 0.31-0.61），而环境效应没有重叠。研究结果表明，这些表型在家庭中聚集在一起，相似的基因或可遗传特征可能导致它们同时发生。
