Wills Amanda G, Evans Luke M, Hopfer Christian
Department of Pharmacology, University of Colorado School of Medicine, 12800 E. 19th Ave., Aurora, CO, 80045, USA.
Institute for Behavioral Genetics, University of Colorado Boulder, 1480 30th Street, Boulder, CO, 80301, USA.
Behav Genet. 2017 May;47(3):290-297. doi: 10.1007/s10519-017-9838-2. Epub 2017 Feb 25.
The health impairments derived from both alcoholism and obesity are well known. However, reports that relate increased alcohol use with increased measures of obesity have been mixed in their findings, especially with respect to genetic factors that could potentially link these two behaviors. Here, using a large sample of adults from the UK (n ≈ 113,000), we report both the observed and genetic correlations between BMI (kg/m) and two measures of alcohol use: reported quantity (drinks per week) and frequency of use (from never to daily). Overall, both observationally and genetically, alcohol intake is negatively correlated with BMI. Phenotypic correlations ranged from -0.01 to -0.17, and genetic correlations ranged from -0.1 to -0.4. Genetic correlations tended to be stronger than the phenotypic correlations, and these correlations were stronger in females and between BMI and, specifically, frequency of use. Though the mechanisms driving these relationships are yet to be identified, we can conclude that the genetic factors related to drinking both more and more often are shared with those responsible for lower BMI.
酗酒和肥胖所导致的健康损害是众所周知的。然而，关于饮酒量增加与肥胖指标上升之间关系的报告，其研究结果并不一致，尤其是在涉及可能将这两种行为联系起来的遗传因素方面。在此，我们使用来自英国的大量成年人样本（n≈113,000），报告了体重指数（BMI，kg/m）与两种饮酒量指标之间的观察到的相关性和遗传相关性：报告的饮酒量（每周饮酒次数）和饮酒频率（从不饮酒到每日饮酒）。总体而言，无论是从观察到的还是遗传的角度来看，酒精摄入量与BMI均呈负相关。表型相关性在-0.01至-0.17之间，遗传相关性在-0.1至-0.4之间。遗传相关性往往比表型相关性更强，并且这些相关性在女性中以及在BMI与饮酒频率之间更强。尽管驱动这些关系的机制尚未确定，但我们可以得出结论，与饮酒量增加和饮酒频率增加相关的遗传因素与导致较低BMI的遗传因素是相同的。
