Zekai Tahir Burak Women Education and Research Hospital, Obstetrics and Gynecology, Devlet Mah. Subay Loj. Hızırreis Apt. No:19/11 Yenisehir, Ankara, Turkey.
J Assist Reprod Genet. 2012 Apr;29(4):325-8. doi: 10.1007/s10815-012-9714-1.
To determine Vit E effect on the treatment outcomes of women with unexplained infertility undergoing controlled ovarian stimulation and intrauterine insemination (IUI).
The study group (Group A, n053) underwent controlled ovarian stimulation with clomiphene citrate with Vit E administration, 400 IU/day p.o. while the control group(Group B, n050) underwent ovulation induction without VitE. Treatment outcomes were compared between the groups.
There were no significant differences between the two groups with respect to the demographic outcomes. The difference in endometrial thickness on the day of hCG administration was significant between the two groups (p00.001).The effect of receiving Vit E on the implantation and the on going pregnancy rates were assesed Odds Ratio (OR) and corresponding 95% Confidence Intervals (CI). Receiving Vit E was not significantly associated with the implantation and the ongoing pregnancy rates; OR 0 1.22, 95% CI (0.44–3.4)and OR 0 1.43, 95% CI (0.49–4.1), respectively.
Vit E administration may improve the endometrial response in unexplained infertile women via the likely antioxidant and the anticoagulant effects. It may also modulate the antiestrogenic effect of clomiphene citrate and the problem of a thin endometrium in these cycles may beadjusted
探讨维生素 E 对不明原因不孕妇女行控制性卵巢刺激和宫腔内人工授精（IUI）治疗结局的影响。
研究组（A 组，n053）接受枸橼酸氯米酚联合维生素 E 治疗，维生素 E 剂量为 400IU/天，口服。对照组（B 组，n050）接受促排卵治疗但不给予维生素 E。比较两组的治疗结局。
两组患者的人口统计学结局无显著差异。两组患者 hCG 给药日的子宫内膜厚度差异有统计学意义（p00.001）。评估维生素 E 对种植率和持续妊娠率的影响，采用比值比（OR）及其 95%置信区间（CI）。维生素 E 的摄入与种植率和持续妊娠率无显著相关性；OR01.22，95%CI（0.44–3.4）和 OR01.43，95%CI（0.49–4.1）。
维生素 E 可能通过其抗氧化和抗凝作用改善不明原因不孕妇女的子宫内膜反应。它还可能调节枸橼酸氯米酚的抗雌激素作用，并调整这些周期中薄型子宫内膜的问题。
