Department of Psychiatry, Ysbyty Maelor, Wrexham, Clwyd LL13 7TD.
J Psychopharmacol. 1996 Jan;10(2):134-40. doi: 10.1177/026988119601000208.
The cognitive and subjective effects of sub-anaesthetic doses of ketamine on healthy volunteers were examined. Twelve healthy volunteers received 25 mg ketamine, 10 mg ketamine and saline placebo, i.m. in a double-blind, Latin square design. A cognitive, perceptual and self-report test battery was administered over 45 min. The order of tests was rotated to control for timing effects. Ketamine (25 mg) significantly affected verbal learning and memory, parallel visual search, some measures of psychomotor performance, measures of arousal, subjective mood ratings and visual perception. Measures of attention and frontal lobe functioning were relatively unaffected. Thus, low doses of ketamine had selective, dose-related effects on memory, perceptual and psychomotor functions. The disruption of memory and perceptual processes may help to explain the unique subjective state induced by ketamine.
研究了亚麻醉剂量氯胺酮对健康志愿者的认知和主观影响。12 名健康志愿者接受了 25mg 氯胺酮、10mg 氯胺酮和生理盐水安慰剂肌内注射，采用双盲、拉丁方设计。在 45 分钟内进行了认知、知觉和自我报告测试。测试的顺序进行了旋转，以控制时间效应。氯胺酮（25mg）显著影响言语学习和记忆、平行视觉搜索、一些心理运动表现的测量、觉醒的测量、主观情绪评分和视觉感知。注意力和额叶功能的测量相对不受影响。因此，低剂量氯胺酮对记忆、知觉和心理运动功能有选择性、剂量相关的影响。记忆和知觉过程的中断可能有助于解释氯胺酮引起的独特的主观状态。
