Abou Basha L M, Salem A I, Fadali G A
Department of Parasitology and Pathology, Alexandria University, Egypt.
J Egypt Soc Parasitol. 1990 Dec;20(2):541-8.
The pathology of human fascioliasis was studied before and after bithionol treatment using light and transmission electron microscopy. Fine needle biopsies were taken from five patients, with established fascioliasis, before and after drug administration. By light microscope the pathology of human fascioliasis was similar to that reported in experimental fascioliasis. The ultrastructural picture revealed bile ductular hyperplasia, fibrosis of portal tracts, widening of the interhepatic spaces by many microvilli and dilated Disse space with collagen fibres. Bile ductular hyperplasia may be the initial factor to fibrinogenesis, which subsequently enhance the development of the microvilli on the surface of the hepatocytes. Both light and electron microscopic studies revealed regression of the picture of fascioliasis to normal after bithionol treatment with no sign of toxicity on the liver.
利用光学显微镜和透射电子显微镜，对硫双二氯酚治疗前后的人体片形吸虫病病理学进行了研究。对五名确诊为片形吸虫病的患者在给药前后进行细针活检。通过光学显微镜观察，人体片形吸虫病的病理学表现与实验性片形吸虫病中所报道的相似。超微结构显示胆管增生、门管区纤维化、肝内间隙因许多微绒毛而增宽以及狄氏间隙扩张并伴有胶原纤维。胆管增生可能是纤维蛋白形成的初始因素，其随后促进肝细胞表面微绒毛的发育。光学显微镜和电子显微镜研究均显示，硫双二氯酚治疗后片形吸虫病的表现恢复正常，且对肝脏无毒性迹象。
