Leidinger Petra, Keller Andreas, Meese Eckart
Institute of Human Genetics, Medical School, Saarland University Homburg, Germany.
Front Genet. 2012 Jan 23;2:104. doi: 10.3389/fgene.2011.00104. eCollection 2011.
MicroRNAs (miRNA) are important regulators of gene expression. They are involved in many physiological processes ensuring the cellular homeostasis of human cells. Alterations of the miRNA expression have increasingly been associated with pathophysiologic changes of cancer cells making miRNAs currently to one of the most analyzed molecules in cancer research. Here, we provide an overview of miRNAs in lung cancer. Specifically, we address biological functions of miRNAs in lung cancer cells, miRNA signatures generated from tumor tissue and from patients' body fluids, the potential of miRNAs as diagnostic and prognostic biomarker for lung cancer, and its role as therapeutic target.
微小RNA（miRNA）是基因表达的重要调节因子。它们参与许多确保人类细胞内环境稳态的生理过程。miRNA表达的改变越来越多地与癌细胞的病理生理变化相关，这使得miRNA成为目前癌症研究中分析最多的分子之一。在此，我们概述了肺癌中的miRNA。具体而言，我们阐述了miRNA在肺癌细胞中的生物学功能、从肿瘤组织和患者体液中产生的miRNA特征、miRNA作为肺癌诊断和预后生物标志物的潜力及其作为治疗靶点的作用。
