Alrubaiy Laith, Al-Rubaiy Kathem K
Oman Med J. 2009 Jan;24(1):4-6. doi: 10.5001/omj.2009.2.
Replacing skin defects has witnessed several developments over the centuries. It started with the introduction of skin grafting by Reverdin in 1871. Since then, varieties of skin grafting techniques have been used successfully. Despite being clinically useful, skin grafts have many limitations including the availability of the donor site especially in circumstances of extensive skin loss, immune rejection in allogenic skin grafts, pain, scarring, slow healing and infection.(1,2) For these reasons, scientist have worked hard to find skin substitutes to replace skin defects without the need for a "natural" skin graft. These materials which are used to cover skin defects are called "Skin substitutes". This article briefly discusses the common types of skin substitutes and their clinical uses.
几个世纪以来，皮肤缺损修复技术取得了多项进展。它始于1871年雷维尔丹引入的皮肤移植术。从那时起，各种皮肤移植技术都已成功应用。尽管皮肤移植在临床上很有用，但它有许多局限性，包括供皮区的可用性，特别是在大面积皮肤缺损的情况下，异体皮肤移植中的免疫排斥、疼痛、瘢痕形成、愈合缓慢和感染。（1,2）由于这些原因，科学家们一直在努力寻找皮肤替代物来替代皮肤缺损，而无需“天然”皮肤移植。这些用于覆盖皮肤缺损的材料被称为“皮肤替代物”。本文简要讨论了常见的皮肤替代物类型及其临床应用。
