Shakespeare Peter G
Laing Laboratory for Burn Injury Investigation, Salisbury District Hospital, Salisbury SP2 8BJ, UK.
Clin Dermatol. 2005 Jul-Aug;23(4):413-8. doi: 10.1016/j.clindermatol.2004.07.015.
Extensive burn wounds are difficult to manage and repair. Several engineered skin substitutes have been developed to aid in this process. These substitutes are designed with particular objectives in mind which dictate the circumstances under which they can, and should, be employed to promote healing or prepare the burn wound for final closure with autograft. This article discusses some of the rationale behind the use of skin substitutes and reviews some of the substitutes in use at the present time. Current perspectives suggest that skin substitute use is still in its infancy and that there is some way to go before their role in clinical practice becomes clear. Nevertheless the prospect of being able to supply new wound repair components and to influence the healing process to modify outcome and improve the quality of the healed burn wound will ensure a continuing high degree of interest in these potentially useful and beneficial medical devices.
大面积烧伤创面难以处理和修复。人们已研发出多种人工皮肤替代品来辅助这一过程。这些替代品在设计时有着特定目标，这些目标决定了在何种情况下可以且应该使用它们来促进愈合，或为最终通过自体移植实现烧伤创面闭合做准备。本文讨论了使用皮肤替代品背后的一些基本原理，并回顾了目前正在使用的一些替代品。当前观点表明，皮肤替代品的使用仍处于起步阶段，在其在临床实践中的作用变得清晰之前，仍有很长的路要走。然而，能够提供新的伤口修复组件并影响愈合过程以改变结果并提高愈合烧伤创面的质量，这一前景将确保人们对这些潜在有用且有益的医疗设备持续保持高度关注。
