Supp Dorothy M, Boyce Steven T
Research Department, Shriners Hospitals for Children, Cincinnati Burns Hospital, Cincinnati, OH 45229, USA.
Clin Dermatol. 2005 Jul-Aug;23(4):403-12. doi: 10.1016/j.clindermatol.2004.07.023.
Wound healing can be problematic in several clinical settings because of massive tissue injury (burns), wound healing deficiencies (chronic wounds), or congenital conditions and diseases. Engineered skin substitutes have been developed to address the medical need for wound coverage and tissue repair. Currently, no engineered skin substitute can replace all of the functions of intact human skin. A variety of biologic dressings and skin substitutes have however contributed to improved outcomes for patients suffering from acute and chronic wounds. These include acellular biomaterials and composite cultured skin analogs containing allogeneic or autologous cultured skin cells.
在多种临床情况下，伤口愈合可能会出现问题，原因包括大面积组织损伤（烧伤）、伤口愈合缺陷（慢性伤口）或先天性疾病。为满足伤口覆盖和组织修复的医疗需求，人们开发了工程皮肤替代品。目前，尚无工程皮肤替代品能够完全替代完整人类皮肤的所有功能。然而，多种生物敷料和皮肤替代品已为急慢性伤口患者带来了更好的治疗效果。这些包括脱细胞生物材料以及含有异体或自体培养皮肤细胞的复合培养皮肤类似物。
