Greulich Philip, Santen Ludger
SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec;84(6 Pt 1):060902. doi: 10.1103/PhysRevE.84.060902. Epub 2011 Dec 27.
We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in the absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent of filament interactions and explicit regulation. It can be understood by an analogy to electrostatics and appears to be induced by the confining boundaries; for periodic boundary conditions, no orientational bias emerges. Including active transport of particles, the model reproduces experimental observations of vesicle accumulations in transected axons.
我们发现了一种统计机制，在没有组织中心的情况下，这种机制可以使细胞内细丝的方向与细胞几何形状相匹配。这种效应基于随机且各向同性的细丝（解）聚合动力学，并且与细丝相互作用和明确的调控无关。它可以通过与静电学的类比来理解，并且似乎是由限制边界所诱导的；对于周期性边界条件，不会出现方向偏差。该模型纳入粒子的主动运输后，再现了横断轴突中囊泡积累的实验观察结果。
