Hess Henry, Tseng Yiider
Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611, USA.
ACS Nano. 2007 Dec;1(5):390-2. doi: 10.1021/nn700407v.
Active transport mechanisms, relying on motor proteins or polymerization of cytoskeletal filaments, play a central role in the uptake of nanoparticles by cells. While active transport can enhance the effectiveness of nanoparticle therapeutics, it also contributes to the toxicity of nanoparticles released to the environment. In work published in an article in this issue, Galya Orr and colleagues investigated the role of active transport in the interaction of different types of silica particles with alveolar epithelial cells, which are found on the inner surface of the lung.
依赖于运动蛋白或细胞骨架丝聚合的主动运输机制，在细胞摄取纳米颗粒过程中发挥着核心作用。虽然主动运输可以提高纳米颗粒治疗的有效性，但它也会导致释放到环境中的纳米颗粒产生毒性。在本期发表的一篇文章中，加利亚·奥尔及其同事研究了主动运输在不同类型二氧化硅颗粒与肺泡上皮细胞相互作用中的作用，肺泡上皮细胞位于肺的内表面。
