Laboratory for Cognition and Neural Stimulation, Department of Neurology, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
Laboratory for Cognition and Neural Stimulation, Department of Neurology, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
Brain Stimul. 2012 Jul;5(3):201-207. doi: 10.1016/j.brs.2011.04.002. Epub 2011 May 5.
Poor reading efficiency is the most persistent problem for adults with developmental dyslexia. Previous research has demonstrated a relationship between left posterior temporal cortex (pTC) function and reading ability, regardless of dyslexia status.
OBJECTIVE/HYPOTHESIS: In this study, we tested whether enhancing left lateralization of pTC using transcranial direct current stimulation (tDCS) improves reading efficiency in adults without dyslexia.
Twenty-five right-handed adults with no history of learning disorder participated. Real and sham "Left lateralizing" tDCS were applied to the pTC in separate sessions. Standardized word and nonword reading tests were given immediately after stimulation.
Modeling of the induced electrical field confirmed that tDCS was likely to increase left pTC excitability and reduce right pTC excitability as intended. Relative to sham, real tDCS induced improvements in word reading efficiency in below average readers.
Enhancing left lateralization of the pTC using tDCS improves word reading efficiency in below-average readers. This demonstrates that left lateralization of the pTC plays a role in reading ability, and provides stimulation parameters that could be used for a trial of tDCS in adults with developmental dyslexia. Such short-term gains could amplify the effect of appropriate reading interventions when performed in conjunction with them.
阅读效率低下是成年发育性阅读障碍者最持久的问题。先前的研究表明，左后颞叶皮层（pTC）的功能与阅读能力有关，而与阅读障碍的状态无关。
目的/假设：在这项研究中，我们测试了使用经颅直流电刺激（tDCS）增强 pTC 的左侧偏侧化是否能提高非阅读障碍成年人的阅读效率。
25 名右利手成年人，无学习障碍史。在单独的疗程中，将真实和假的“左侧化”tDCS 应用于 pTC。刺激后立即进行标准化的单词和非单词阅读测试。
诱导电场的建模证实，tDCS 可能会增加左 pTC 的兴奋性，降低右 pTC 的兴奋性，这与预期相符。与假刺激相比，真实 tDCS 诱导了阅读能力低于平均水平的个体的单词阅读效率提高。
使用 tDCS 增强 pTC 的左侧偏侧化可提高阅读能力低于平均水平的个体的单词阅读效率。这表明 pTC 的左侧偏侧化在阅读能力中起着作用，并提供了刺激参数，可用于对发育性阅读障碍的成年人进行 tDCS 试验。当与适当的阅读干预措施一起进行时，这些短期的收益可能会放大它们的效果。
