度洛西汀中毒导致全面性强直-阵挛发作：一则预后良好的简短报告。

Generalized tonic-clonic seizure secondary to duloxetine poisoning: a short report with favorable out come.

机构信息

Child Neuropsychiatry Unit, University of Bologna, Italy.

出版信息

Neurotoxicology. 2012 Mar;33(2):189-90. doi: 10.1016/j.neuro.2012.01.009. Epub 2012 Jan 25.

DOI:10.1016/j.neuro.2012.01.009

Abstract

Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) with a weak activity over dopamine reuptake used in the treatment of major depressive disorder. Daily doses of 60 mg are effective in treatment of major depression. There are few cases of isolated duloxetine overdose in humans. We think this is the first report of a generalized tonic-clonic seizure following isolated duloxetine poisoning with a very high dosage.

摘要

度洛西汀是一种强效且选择性的 5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI），对多巴胺再摄取的活性较弱，用于治疗重度抑郁症。每日 60 毫克的剂量对治疗重度抑郁症有效。在人类中，孤立的度洛西汀过量的情况很少见。我们认为这是首例报告的在单独服用度洛西汀中毒且剂量非常高的情况下发生的全身性强直阵挛发作。